PHO related genes

Gene	ORF	PHO- regulated	Function	Motif
PHO2/BAS2/GRF10	YDL106C		Transcriptional activator	homeodomain
PHO3	YBR092C		constitutive acid phosphatase (p57), thiamine phosphatatase	similar to Pho5
PHO4	YFR034C		PHO-specific transcriptional activator	Helix-Loop-Helix
PHO5	YBR093C	yes	repressible acid phosphatase (p60)
PHO6/THI2	YBR240C		positive regulator for PHO3
PHO7			positive regulator for PHO3
PHO8	YDR481C		repressible vacuolar alkaline phosphatase, fructose-2,6-bisphsphate phosphatase
PHO9/PEP4	YPL154C		vacuolar proteinase A, reauired for maturation of Pho8 and Phm5
(PHO10)			= PHO12
PHO11	YAR071W	yes	repressible acid phosphatase (p56)	Pho5 homolog
PHO12	YHR215W	yes	repressible acid phosphatase (p58)	Pho5 homolog
PHO13	YDR236W		vacuolar alkaline phosphatase, (p-nitrophosphate scpecific)
PHO23	YNL097C			similar to human p33ING1
PHO80	YOL001W		Pho85 cyclin	pcl family
PHO81	YGR233C	yes	CDK inhibitor for Pho80-Pho85	Ankyrin repeat, Pi domain
(PHO82)			= PHO4c mutation allele
(PHO83)			= Ty insertion on PHO5 promoter
PHO84	YML123C	yes	high-affinity H+/Pi cotransporter	12 transmembrane segments
PHO85	TPL031C		cyclin dependent protein kinase	CDK family
PHO86	YJL117W	yes	ER protein involved in an ER exit step of Pho84
PHO87	YCR037C		putative Pi transporter	Pi domain, 12 transmembrane segments
PHO88	YBR106W		similar function to PHO86	membrane protein
PHO89	YBR296C	yes	Na+/Pi cotransporter	12 transmembrane segments
PSE1/KAP121	YMR308C		Nuclear import for Pho4	beta-inportin
MSN5/KAP142	YDR335W		Nuclear export for Pho4	beta-inportin
SPL2	YHR136C	yes	Pho81 homolog	Ankyrin repeat
YPL110C	YPL110C	yes	Pho81 homolog	Ankyrin repeat
PHM1/VTC2	YFL004W	yes	involved in polyphosphate synthesis	Pi domain
PHM2/VTC3	YPL019C	yes	nvolved in polyphosphate synthesis	Pi domain
PHM3/VTC4	YJL012C	yes	nvolved in polyphosphate synthesis	Pi domain
PHM4/VTC1/NRF1	YER072W	yes	nvolved in polyphosphate synthesis, vacuolar transporter chaperon	Pi domain
PHM5	YDR452W	yes	vacuolar polyphosphatase	similar to acid sphingomyelinase
PHM6	YDR281C	yes
PHM7	YOL084W	yes		similar to YMR266W
PHM8	YER037W	yes		similar to YGL224C
HOR2/GPP2	YER062C	yes	DL-glycerol phosphatase
CTF19	YPL018W	yes	chromosome segregation
HIS1	YER055C	yes	ATP phospharibosyltransferase

September 15, 2000